Lindgren L, Saarnivaara L
Acta Anaesthesiol Scand. 1986 Aug;30(6):444-6. doi: 10.1111/j.1399-6576.1986.tb02449.x.
Eighty-three children with a mean age of 2.7 years were anaesthetized with either thiopental 5 mg/kg followed by suxamethonium 1.5 mg/kg i.v. or with enflurane 5 vol% in 70% nitrous oxide in oxygen via a face mask. In the enflurane group, venepuncture was performed when the children were unconscious, 1.8 +/- 0.05 (s.e.) min after the start of anaesthesia. After enflurane, suxamethonium 1, 1.5 or 2 mg/kg was administered i.v. for endotracheal intubation. The incidence and duration of muscle fasciculations after suxamethonium were significantly lower (P less than 0.01) in the enflurane groups than in the thiopental group. The fasciculation index was significantly lower (P less than 0.01) in the enflurane groups than in the thiopental group. In the enflurane groups, intubating conditions were better (P less than 0.05) in the children treated with suxamethonium 2 mg/kg than in those treated with suxamethonium 1 mg/kg.
八十三名平均年龄为2.7岁的儿童接受麻醉，其中一组静脉注射硫喷妥钠5毫克/千克，随后静脉注射琥珀胆碱1.5毫克/千克；另一组通过面罩吸入含5%体积比安氟醚的70%氧化亚氮和氧气混合气体。在安氟醚组中，麻醉开始1.8±0.05（标准误）分钟后，待儿童失去意识时进行静脉穿刺。使用安氟醚麻醉后，静脉注射1、1.5或2毫克/千克琥珀胆碱进行气管插管。安氟醚组琥珀胆碱注射后肌肉震颤的发生率和持续时间显著低于硫喷妥钠组（P<0.01）。安氟醚组的震颤指数也显著低于硫喷妥钠组（P<0.01）。在安氟醚组中，接受2毫克/千克琥珀胆碱治疗的儿童插管条件优于接受1毫克/千克琥珀胆碱治疗的儿童（P<0.05）。
