Long E D, Shepherd R T
Br J Urol. 1983 Apr;55(2):189-94. doi: 10.1111/j.1464-410x.1983.tb06553.x.
One hundred and six bladders were removed at autopsy from adult women dying of diseases unrelated to the urinary tract. A fixative solution had been introduced into the bladder as soon as possible after death. The naked-eye appearances were recorded before and after application of Lugol's iodine solution and the trigones then submitted to histological examination. Vaginal metaplasia of the trigone was present in the majority (72%) of bladders, a similar incidence being found in both pre-menopausal and post-menopausal age groups. Histological evidence of chronic inflammation was found significantly more frequently in bladders showing vaginal metaplasia and it is suggested that vaginal metaplasia is not a consequence of chronic inflammation but that its surface characteristics may predispose to chronic infection. Its purported hormonal aetiology does not explain all observed features. Prominent venous channels within the tunica propria around the urethral orifice were a constant feature in all bladders studied. Two of the 76 bladders showing vaginal metaplasia also displayed atypical hyperplasia of this squamous epithelium, a previously unrecorded observation. The possible implications of such atypical hyperplasia are briefly discussed.
从死于与尿路无关疾病的成年女性尸体上解剖取出106个膀胱。死后尽快向膀胱内注入固定液。在应用卢戈氏碘溶液前后记录肉眼外观，然后将膀胱三角区送去做组织学检查。大多数（72%）膀胱存在膀胱三角区阴道化生，在绝经前和绝经后年龄组中发生率相似。在显示阴道化生的膀胱中，慢性炎症的组织学证据明显更常见，提示阴道化生不是慢性炎症的结果，但其表面特征可能易患慢性感染。其所谓的激素病因并不能解释所有观察到的特征。在所研究的所有膀胱中，尿道外口周围固有层内明显的静脉通道是一个恒定特征。76个显示阴道化生的膀胱中有2个也表现出这种鳞状上皮的非典型增生，这是以前未记录到的观察结果。简要讨论了这种非典型增生的可能影响。
