对由未诱导和诱导的来自查尔斯河CD大鼠及斯普拉格-道利大鼠的大鼠肝微粒体形成的α-萘黄酮二氢二醇结构的重新分析与阐释。
Reanalysis and clarification of the structures of alpha-naphthoflavone dihydrodiols formed by uninduced and induced rat liver microsomes from Charles River CD and Sprague-Dawley rats.
作者信息
Nesnow S, Bryant B J, Rudo K, Easterling R
出版信息
Carcinogenesis. 1983;4(4):425-30. doi: 10.1093/carcin/4.4.425.
The structures of alpha-naphthoflavone (ANF) dihydrodiols formed by uninduced and induced rat liver microsomes are identified by conversion of the metabolically formed ANF-dihydrodiols to the corresponding phenols. Comparison of these phenols with synthetic standards provides an unambiguous method for structural identification. The results of these studies are that hepatic microsomes from uninduced or phenobarbital, Aroclor-1254, 3-methylcholanthrene, or 5,6-benzoflavone induced Sprague-Dawley or Charles River CD rats each produce a major and a minor ANF-dihydrodiol identified as ANF-7,8-dihydrodiol and ANF-5,6-dihydrodiol, respectively.
通过将代谢形成的α-萘黄酮（ANF）二氢二醇转化为相应的酚类，鉴定了未诱导和诱导的大鼠肝微粒体形成的ANF二氢二醇的结构。将这些酚类与合成标准品进行比较，为结构鉴定提供了一种明确的方法。这些研究的结果是，来自未诱导或经苯巴比妥、多氯联苯混合物Aroclor-1254、3-甲基胆蒽或5,6-苯并黄酮诱导的斯普拉格-道利大鼠或查尔斯河CD大鼠的肝微粒体，各自产生一种主要的和一种次要的ANF二氢二醇，分别鉴定为ANF-7,8-二氢二醇和ANF-5,6-二氢二醇。
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