Oster O, Prellwitz W, Kasper W, Meinertz T
Clin Chim Acta. 1983 Feb 28;128(1):125-32. doi: 10.1016/0009-8981(83)90062-1.
A deficiency of selenium is suspected to be involved in the pathogenesis of congestive cardiomyopathy. Therefore the serum selenium content of 20 patients with proven congestive cardiomyopathy was measured and compared to that of a healthy control group. The serum selenium content of the patients with cardiomyopathy was found to be different from that of the healthy control group. The mean value of selenium in serum for the control group was 80.1 micrograms Se/1 (SD +/- 13.2) within a range of 53 and 117 micrograms Se/1. From the 20 patients with congestive cardiomyopathy six patients showed selenium concentrations in the normal value range of the control group; in the serum of 14 patients a distinct lower selenium content was found (mean value 47.8 micrograms Se/1 (SD +/- 16.2)) within a range of 23 and 70 micrograms Se/1. A positive correlation was found between serum selenium content and the left ventricular ejection fraction. Our results suggest that a deficiency of selenium may be present in a number of patients with congestive cardiomyopathy.
硒缺乏被怀疑与充血性心肌病的发病机制有关。因此，对20例已确诊的充血性心肌病患者的血清硒含量进行了测定，并与健康对照组进行了比较。发现心肌病患者的血清硒含量与健康对照组不同。对照组血清硒的平均值为80.1微克硒/升（标准差±13.2），范围在53至117微克硒/升之间。在20例充血性心肌病患者中，有6例患者的硒浓度在对照组的正常范围内；在14例患者的血清中发现硒含量明显较低（平均值47.8微克硒/升（标准差±16.2）），范围在23至70微克硒/升之间。血清硒含量与左心室射血分数之间存在正相关。我们的结果表明，许多充血性心肌病患者可能存在硒缺乏。
