Krim Selim R, Campbell Patrick, Lavie Carl J, Ventura Hector
Department of Cardiology, John Ochsner Heart and Vascular Institute, Ochsner Clinical School-The University of Queensland School of Medicine, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA.
Curr Heart Fail Rep. 2013 Mar;10(1):46-53. doi: 10.1007/s11897-012-0118-4.
Heart failure (HF)-associated mortality remains high, despite guideline-recommended medical therapies. Poor nutritional status and unintentional cachexia have been shown to have a strong association with worse survival in HF patients. Importantly, micronutrient deficiencies are potential contributing factors to the progression of HF. This review aims to summarize contemporary evidence on the role of micronutrients in the pathophysiology and outcome of HF patients. Emphasis will be given to the most well-studied micronutrients, specifically, vitamin D, vitamin B complex, coenzyme Q10 and L-carnitine.
尽管有指南推荐的药物治疗，但心力衰竭（HF）相关的死亡率仍然很高。营养状况不佳和非故意性恶病质已被证明与HF患者较差的生存率密切相关。重要的是，微量营养素缺乏是HF进展的潜在促成因素。本综述旨在总结关于微量营养素在HF患者病理生理学和预后中作用的当代证据。将重点关注研究最多的微量营养素，特别是维生素D、复合维生素B、辅酶Q10和左旋肉碱。
