Goh T H, Sinnathuray T A, Sivanesaratnam V, Sen D K, Lim L S, Ratnam S S, Karim S M, McCarthy T, Hutapea H, Hanafiah M J, Simandjuntak P
Contraception. 1983 Jan;27(1):75-84. doi: 10.1016/0010-7824(83)90058-6.
Two new Cu-IUDs, the TCu-22OC and Multiload Cu250, were evaluated against the Cu7 in 1,199 subjects in a randomised, multicentric trial using a common study protocol. During the 2 years following insertion, cumulative first-segment rates for total use-related terminations showed no significant differences between the 3 devices; however, the Cu7 had a significantly higher termination rate for accidental pregnancy compared to the TCu-22OC and its expulsion rate was significantly higher than the ML Cu250. The rate of accidental pregnancy was higher and the expulsion rate lower with the ML Cu250 compared to the TCu-22OC but these differences were not significant. The results are discussed in relation to IUD design and their application in family planning.
在一项采用通用研究方案的随机多中心试验中，对1199名受试者使用两种新型铜宫内节育器（TCu - 220C和多负载铜250）与铜7宫内节育器进行了评估。在插入后的2年中，三种节育器因与使用相关的原因导致的累积首段终止率无显著差异；然而，与TCu - 220C相比，铜7因意外妊娠导致的终止率显著更高，其脱落率也显著高于多负载铜250。与TCu - 220C相比，多负载铜250的意外妊娠率更高，脱落率更低，但这些差异并不显著。结合宫内节育器的设计及其在计划生育中的应用对结果进行了讨论。
