拟胆碱药对大鼠脑视觉系统葡萄糖利用的影响。

Effects of cholinomimetics on glucose utilization in rat brain optic systems.

作者信息

Dam M, London E D

出版信息

Eur J Pharmacol. 1983 Jan 28;87(1):137-40. doi: 10.1016/0014-2999(83)90060-2.

Abstract

Physostigmine and oxotremorine effects on local cerebral glucose utilization (LCGU) in rat brain optic systems were examined by the [14C]2-deoxy-D-glucose procedure. Both drugs significantly stimulated LCGU in the superior colliculus (superficial layer) and nucleus of the optic tract, but not in the visual cortex. Physostigmine, but not oxotremorine, stimulated LCGU in components of the accessory optic system. The effects in the accessory optic system apparently result from nicotinic actions of physostigmine.

摘要

采用[14C]2-脱氧-D-葡萄糖法研究了毒扁豆碱和氧化震颤素对大鼠脑视系统局部脑葡萄糖利用（LCGU）的影响。两种药物均显著刺激上丘（表层）和视束核的LCGU，但对视觉皮层无此作用。毒扁豆碱而非氧化震颤素刺激了附属视系统各部分的LCGU。毒扁豆碱在附属视系统中的作用显然源于其烟碱样作用。