Dow-Edwards D, Dam M, Peterson J M, Rapoport S I, London E D
Brain Res. 1981 Dec 7;226(1-2):281-9. doi: 10.1016/0006-8993(81)91100-8.
The [14C]2-deoxy-D-glucose technique was used to test the effects of central muscarinic stimulation on local cerebral glucose utilization (LCGU) in rats. Systemic administration of the muscarinic agonist oxotremorine (OXO, 0.7 mg/kg, ip) increased LCGU in brain regions involved in motor function: the sensorimotor cortex; the extrapyramidal motor system, including the striatum, globus pallidus, red nucleus, substantia nigra, subthalamus and ventral nucleus of the thalamus; the cerebellar vermis, fastigial nucleus and nucleus interpositus; and the vestibular nucleus. No effects were observed in the fibers of the pyramidal tract, internal capsule, cerebellar white matter and the dentate nucleus. Increases were not affected by methylatropine (1 mg/kg sc), but were completely antagonized by scopolamine (2.5 mg/kg, ip). The anatomic distribution and magnitude of the LCGU response to OXO were not simply correlated with the reported densities of muscarinic receptors.
采用[14C]2-脱氧-D-葡萄糖技术来检测中枢毒蕈碱刺激对大鼠局部脑葡萄糖利用（LCGU）的影响。毒蕈碱激动剂氧化震颤素（OXO，0.7mg/kg，腹腔注射）全身给药可增加参与运动功能的脑区的LCGU，这些脑区包括感觉运动皮层；锥体外系运动系统，包括纹状体、苍白球、红核、黑质、丘脑底核和丘脑腹侧核；小脑蚓部、顶核和间位核；以及前庭核。在锥体束纤维、内囊、小脑白质和齿状核中未观察到影响。氧化震颤素引起的增加不受甲基阿托品（1mg/kg，皮下注射）的影响，但被东莨菪碱（2.5mg/kg，腹腔注射）完全拮抗。对氧化震颤素的LCGU反应的解剖分布和幅度与所报道的毒蕈碱受体密度并无简单的相关性。
