Hoshino M
Arerugi. 1989 Dec;38(12):1302-10.
Plasma levels of arachidonic acid metabolites, such as thromboxane A2 (TXA2), prostacyclin (PGI2) and leukotrienes (LTS) were measured in patients with exercise-induced asthma (EIA). Asthmatic patients were exercised by treadmill. Before, immediately after and at 5, 15 and 30 minutes after exercise, pulmonary function tests were performed and peripheral venous blood was collected at the indicated times. Plasma TXB2 levels rose after exercise, and this tendency was stronger in EIA negative patients than in EIA positive patients. Plasma 6-keto-PGF1 alpha levels rose slightly after exercise in both EIA positive and negative patients. Plasma LTC4 levels were almost unchanged after exercise in EIA positive patients. Plasma LTC4 levels rose after exercise in EIA negative patients, though the value was always higher in EIA positive patients than in EIA negative patients. Plasma LTB4 levels in both EIA positive and negative patients increased slightly till 5 minutes after exercise, then decreased, and then tended to rise again. Plasma LTB4 levels were higher in EIA positive patients than in EIA negative patients at all times. The ratio of TXB2 to 6-keto-PGF1 alpha after exercise rose more remarkably in EIA negative patients than in EIA positive patients. From these results, we suspected that the metabolites of arachidonic acid may contribute less to chemical mediators of EIA, but the arachidonic acid products of EIA positive patients activated rather towards lipoxygenase cascade than EIA negative patients.
在运动诱发性哮喘（EIA）患者中检测了血浆中花生四烯酸代谢产物的水平，如血栓素A2（TXA2）、前列环素（PGI2）和白三烯（LTS）。哮喘患者通过跑步机进行运动。在运动前、运动后即刻以及运动后5、15和30分钟，进行肺功能测试，并在指定时间采集外周静脉血。运动后血浆TXB2水平升高，且这种趋势在EIA阴性患者中比在EIA阳性患者中更强。在EIA阳性和阴性患者中，运动后血浆6-酮-PGF1α水平均略有升高。EIA阳性患者运动后血浆LTC4水平几乎未变。EIA阴性患者运动后血浆LTC4水平升高，不过EIA阳性患者的值始终高于EIA阴性患者。EIA阳性和阴性患者的血浆LTB4水平在运动后5分钟内均略有升高，然后下降，随后又趋于再次升高。在所有时间点，EIA阳性患者的血浆LTB4水平均高于EIA阴性患者。运动后EIA阴性患者中TXB2与6-酮-PGF1α的比值升高比EIA阳性患者更显著。从这些结果来看，我们怀疑花生四烯酸代谢产物对EIA化学介质的贡献可能较小，但EIA阳性患者的花生四烯酸产物相对于EIA阴性患者更倾向于激活脂氧合酶级联反应。
