Kyriazis A A, Kyriazis A P, Kereiakes J G, Soloway M S, McCombs W B
Exp Cell Biol. 1983;51(2):83-95. doi: 10.1159/000163178.
The histopathologic changes following chemotherapy treatment of a number of human tumors grown in nude mice were evaluated. On the basis of the histopathologic profile, three response levels were recognized--a mild response, a moderate response and a severe response. Severe response was characterized by arrest of cell division and profound nuclear-cytoplasmic degenerative changes. Regrowth of effectively treated tumors originated in clusters of cells most probably representing resistant tumor cell clones. Histopathologic changes represent a sensitive indicator of the response of nude mouse grown human tumors to anticancer agents. Availability and correct interpretation of the post-treatment histopathologic picture is of importance in selecting the proper combination treatment which would maximize tumor response.
对在裸鼠体内生长的多种人类肿瘤进行化疗后的组织病理学变化进行了评估。根据组织病理学特征，识别出三种反应水平——轻度反应、中度反应和重度反应。重度反应的特征是细胞分裂停止以及显著的核质退行性变化。有效治疗后肿瘤的再生长起源于最有可能代表耐药肿瘤细胞克隆的细胞簇。组织病理学变化是裸鼠体内生长的人类肿瘤对抗癌药物反应的敏感指标。治疗后组织病理学图像的可得性和正确解读对于选择能使肿瘤反应最大化的合适联合治疗至关重要。
