Giovanella B C, Stehlin J S, Williams L J, Lee S S, Shepard R C
Cancer. 1978 Nov;42(5):2269-81. doi: 10.1002/1097-0142(197811)42:5<2269::aid-cncr2820420527>3.0.co;2-f.
More than 200 human cancers have been successfully transplanted into nude athymic mice in our laboratory. Strict sterile techniques must be applied in caring for these animals and meticulous attention given to the preparation of the surgical specimens. That the tumors remain human in the mice has been documented by isozyme and karyotype analyses. Also, histopathologic comparisons between the original human tumors and their transplanted counterparts in the mice are strikingly similar or identical. Preliminary results of chemotherapy of human cancers in the nude mice are extremely encouraging. At this point, we believe that the greatest potential for the nude mice lies in their use in testing anticancer therapies for human neoplasms without placing the patients at risk.
在我们实验室，已成功将200多种人类癌症移植到无胸腺裸鼠体内。照料这些动物时必须采用严格的无菌技术，并且要格外精心地准备手术标本。通过同工酶和核型分析已证明，这些肿瘤在小鼠体内仍保持人类肿瘤的特性。此外，原始人类肿瘤与其在小鼠体内的移植对应物之间的组织病理学比较结果惊人地相似或完全相同。裸鼠体内人类癌症化疗的初步结果非常令人鼓舞。就此而言，我们认为裸鼠的最大潜力在于可用于测试针对人类肿瘤的抗癌疗法，而不会让患者面临风险。
