Takahashi M, Kokubo T, Furukawa F, Kurokawa Y, Tatematsu M, Hayashi Y
Gan. 1983 Feb;74(1):28-34.
The influence of sodium chloride on chemical carcinogenesis of the gastroduodenal tract was examined in male outbred Wistar rats exposed to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in the drinking water (100 mg/liter) for 20 weeks. Sodium chloride given concomitantly with MNNG during the first 20 weeks of the experiment increased both the incidence and the size of tumors at 40 weeks. However, sodium chloride given after MNNG during the second 20 weeks of the experiment did not enhance tumor development. This study indicates that, although sodium chloride given with MNNG enhances tumor development, sodium chloride does not promote gastric carcinogenesis.
在饮用含100毫克/升N-甲基-N'-硝基-N-亚硝基胍（MNNG）的水20周的雄性远交系Wistar大鼠中，研究了氯化钠对胃十二指肠化学致癌作用的影响。在实验的前20周，与MNNG同时给予氯化钠，可增加40周时肿瘤的发生率和大小。然而，在实验的第二个20周，在MNNG之后给予氯化钠并不能促进肿瘤发展。这项研究表明，虽然与MNNG同时给予氯化钠可增强肿瘤发展，但氯化钠并不能促进胃癌发生。
