银杏叶提取物对兔离体主动脉的影响。

Effects of an extract of Ginkgo biloba on rabbit isolated aorta.

Auguet M, DeFeudis F V, Clostre F, Deghenghi R

Gen Pharmacol. 1982;13(3):225-30. doi: 10.1016/0306-3623(82)90093-3.

Abstract

Extract of Ginkgo biloba (Gb) provoked a dose-dependent contraction of spirally-cut rabbit aortic strips (EC50 congruent to 1.0 mg/ml) by an action that was antagonized by phentolamine (10(-7) M). 2. Inhibitors of catecholamine re-uptake, cocaine (10(-5) M) and desipramine (10(-7) M) potentiated the contractile effect of norepinephrine (NE), but inhibited the contractile effects of Gb and tyramine. 3. A comparison of the actions of Gb, NE and tyramine using aortic strips prepared from control and reserpine-treated rabbits revealed that reserpine treatment increased the response to NE but decreased the response to Gb and tyramine. 4. The contractile action of Gb on rabbit isolated aorta involves, at least in part, a release of catecholamines from endogenous tissue stores.

摘要

银杏提取物（Gb）可引起螺旋形切割的兔主动脉条产生剂量依赖性收缩（半数有效浓度约为1.0毫克/毫升），其作用可被酚妥拉明（10⁻⁷摩尔/升）拮抗。2. 儿茶酚胺再摄取抑制剂可卡因（10⁻⁵摩尔/升）和地昔帕明（10⁻⁷摩尔/升）增强了去甲肾上腺素（NE）的收缩作用，但抑制了Gb和酪胺的收缩作用。3. 用对照兔和利血平处理的兔制备的主动脉条比较Gb、NE和酪胺的作用，结果显示利血平处理增加了对NE的反应，但降低了对Gb和酪胺的反应。4. Gb对兔离体主动脉的收缩作用至少部分涉及内源性组织储存中儿茶酚胺的释放。