银杏叶提取物与某些神经递质对家兔离体腔静脉收缩作用的比较。

Comparison of the contractile effects of an extract of Ginkgo biloba and some neurotransmitters on rabbit isolated vena cava.

作者信息

Hellegouarch A, Baranès J, Clostre F, Drieu K, Braquet P, DeFeudis F V

出版信息

Gen Pharmacol. 1985;16(2):129-32. doi: 10.1016/0306-3623(85)90049-7.

Abstract

Dose-related contractions were elicited in strips of rabbit isolated vena cava by norepinephrine (NE, IC50 approximately equal to 2.3 X 10(-7) M), dopamine (IC50 approximately equal to 6.9 X 10(-6) M), histamine (IC50 approximately equal to 2.1 X 10(-6) M) and extract of Ginkgo biloba (Gb, IC50 approximately equal to 86 micrograms/ml). Serotonin and tyramine elicited very weak contractile effects in this preparation. Phenoxybenzamine (10(-7) M) abolished the contractions elicited by NE, and blocked the effect of Gb by about 50%. Further support is provided for the therapeutic action of Gb in cardiovascular disorders.

摘要

去甲肾上腺素（NE，半数抑制浓度[IC50]约等于2.3×10⁻⁷M）、多巴胺（IC50约等于6.9×10⁻⁶M）、组胺（IC50约等于2.1×10⁻⁶M）和银杏提取物（Gb，IC50约等于86微克/毫升）可使兔离体腔静脉条产生剂量相关的收缩。5-羟色胺和酪胺在此制剂中引起非常微弱的收缩作用。酚苄明（10⁻⁷M）可消除NE引起的收缩，并使Gb的作用阻断约50%。这为Gb在心血管疾病中的治疗作用提供了进一步的支持。