Kjaeldgaard A, Larsson B
Gynecol Obstet Invest. 1983;15(4):223-9. doi: 10.1159/000299414.
In the present study, the fibrinolytic activity of dorsal foot veins (FAV) was histochemically determined in 46 young and middle-aged healthy women, 26 of whom were using combined contraceptive pills (CCP). Significantly reduced FAV was demonstrated in women with a history of previous thrombophlebitis or family manifestation of deep venous thrombosis irrespective of age, as well as in middle-aged women using CCP, whereas the FAV of young women was uninfluenced by CCP and smoking. The FAV of the smoking middle-aged pill users was significantly reduced as compared to that of the young smoking pill users. With reference to this significant reduction of FAV it might be concluded that the combined contraceptive pill is unsuitable for middle-aged female smokers.
在本研究中，对46名中青年健康女性的足背静脉纤溶活性（FAV）进行了组织化学测定，其中26名女性正在使用复方避孕药（CCP）。有既往血栓性静脉炎病史或深静脉血栓家族史的女性，无论年龄大小，其FAV均显著降低，使用CCP的中年女性也是如此，而年轻女性的FAV不受CCP和吸烟的影响。与年轻吸烟的服药女性相比，中年吸烟的服药女性的FAV显著降低。鉴于FAV的这种显著降低，可以得出结论，复方避孕药不适用于中年吸烟女性。
