Püschel K, Thomasch P, Arnold W
Forensic Sci Int. 1983 Mar-Apr;21(2):181-6. doi: 10.1016/0379-0738(83)90108-1.
By means of radioimmunoassay-technique, hair samples of users, drug related fatalities, carcinoma patients receiving morphine and of experimental guinea pigs receiving codeine were investigated for opiates. The RIA-investigations require a minimum of material; our routine procedures need only 50 mg of hair. No correlation existed between administered doses of opiates and their concentrations in hair of both human and experimental animals. By sectioning the hair, the approximate period of drug use in man could be detected. However, these findings could not be confirmed by the animal experiments. The growth rate of the hair, diffusion and adhesion processes may influence the transport of drugs along the hair. External contaminations and washing procedures were shown to increase or diminish the drug concentration of the samples.
通过放射免疫分析技术，对使用者、与毒品相关的死亡者、接受吗啡治疗的癌症患者以及接受可待因的实验豚鼠的毛发样本进行了阿片类药物检测。放射免疫分析检测所需材料最少；我们的常规程序仅需50毫克毛发。无论是人类还是实验动物，所使用的阿片类药物剂量与其毛发中的浓度之间均无相关性。通过对毛发进行切片，可以检测出人类使用药物的大致时间段。然而，这些发现无法通过动物实验得到证实。头发生长速度、扩散和附着过程可能会影响药物沿毛发的传输。已表明外部污染和清洗程序会增加或降低样本中的药物浓度。
