Bachmann E, Weber E, Post M, Zbinden G
Pharmacology. 1978;17(1):39-49. doi: 10.1159/000136833.
Repeated oral administration of commonly used suspending media, gum arabic, gum tragacanth, methylcellulose, and carboxymethylcellulose-Na to rats caused uncoupling of oxidative phosphorylation in liver and heart mitochondria and partial inhibition of mixed function oxidases of liver endoplasmic reticulum, as measured by 2-biphenylhydroxylation and 4-biphenylhydroxylation. There were considerable differences between the compounds with regard to potency and reversibility of these effects. Only methylcellulose at a concentration of 0.5% did not alter mitochondrial function and mixed function oxidases. It is recommended as suspending medium for the use in pharmacological and toxicological experiments.
对大鼠反复口服常用的助悬剂阿拉伯胶、西黄蓍胶、甲基纤维素和羧甲基纤维素钠，会导致肝脏和心脏线粒体氧化磷酸化解偶联，并部分抑制肝脏内质网的混合功能氧化酶，这通过2-联苯羟基化和4-联苯羟基化来测定。这些化合物在这些作用的效力和可逆性方面存在相当大的差异。只有浓度为0.5%的甲基纤维素不会改变线粒体功能和混合功能氧化酶。推荐将其作为助悬剂用于药理学和毒理学实验。
