作为单唾液酸神经节苷脂分离出的抗胃肠道肿瘤相关抗原的单克隆抗体。

Monoclonal antibodies against gastrointestinal tumour-associated antigens isolated as monosialogangliosides.

作者信息

Lindholm L, Holmgren J, Svennerholm L, Fredman P, Nilsson O, Persson B, Myrvold H, Lagergård T

出版信息

Int Arch Allergy Appl Immunol. 1983;71(2):178-81. doi: 10.1159/000233384.

Abstract

Monoclonal antibodies were produced after immunization of mice with a colorectal adenocarcinoma cell line or liver metastasis membranes from a patient with colon adenocarcinoma. Many monoclonal antibodies were found to react with colorectal adenocarcinoma cells but not with normal colon mucosa, blood lymphocytes, myeloma cells or lung epithelial carcinoma cells. Three of these 'colorectal tumour-specific' antibodies appear to define different antigens that were found in the complex monosialoganglioside fraction from 60 to 90% of the colorectal and pancreatic adenocarcinoma tumours or metastases examined but essentially lacking in normal colon mucosa and other normal or tumour tissues tested.

摘要

用结肠直肠腺癌细胞系或一名结肠腺癌患者的肝转移膜免疫小鼠后产生了单克隆抗体。发现许多单克隆抗体与结肠直肠腺癌细胞发生反应，但与正常结肠黏膜、血液淋巴细胞、骨髓瘤细胞或肺上皮癌细胞不发生反应。其中三种“结肠直肠肿瘤特异性”抗体似乎定义了不同的抗原，这些抗原在60%至90%的所检测的结肠直肠和胰腺腺癌肿瘤或转移灶的复合单唾液酸神经节苷脂部分中被发现，但在所检测的正常结肠黏膜和其他正常或肿瘤组织中基本不存在。