Lehtonen A, Hietanen E, Marniemi J, Peltonen P, Nikkilä E A
Int J Clin Pharmacol Ther Toxicol. 1983 Feb;21(2):73-6.
Serum total cholesterol, HDL cholesterol, triglycerides, and adipose tissue lipoprotein lipase activity were analyzed in seven hypertensive subjects using 160-480 mg sotalol daily, before and after a 3-week pause in the treatment. Triglycerides decreased and HDL cholesterol increased significantly during the break in sotalol treatment, whereas no changes occurred in total cholesterol and lipoprotein lipase. A positive correlation was found after the interruption between the lipoprotein lipase activity and the HDL cholesterol concentration. This correlation did not exist before the break in the drug treatment. On the basis of these results the effects of sotalol on lipoprotein metabolism do not seem to be mediated by lipoprotein lipase.
对7名高血压患者进行分析，他们每天服用160 - 480毫克索他洛尔，在治疗中断3周前后分别检测血清总胆固醇、高密度脂蛋白胆固醇、甘油三酯和脂肪组织脂蛋白脂肪酶活性。在索他洛尔治疗中断期间，甘油三酯降低，高密度脂蛋白胆固醇显著升高，而总胆固醇和脂蛋白脂肪酶无变化。中断治疗后发现脂蛋白脂肪酶活性与高密度脂蛋白胆固醇浓度之间呈正相关。在药物治疗中断前不存在这种相关性。基于这些结果，索他洛尔对脂蛋白代谢的影响似乎不是由脂蛋白脂肪酶介导的。
