原发性骨髓增生异常综合征中环铁幼粒细胞的患病率及分布情况。
Prevalence and distribution of ringed sideroblasts in primary myelodysplastic syndromes.
作者信息
Juneja S K, Imbert M, Sigaux F, Jouault H, Sultan C
出版信息
J Clin Pathol. 1983 May;36(5):566-9. doi: 10.1136/jcp.36.5.566.
In order to determine the prevalence and percentage distribution of ringed sideroblasts in primary myelodysplastic syndromes, the results of Prussian blue staining were analysed in 133 cases. Ringed sideroblasts ranging from 1 to 86% of cells were found in 76 (57%) cases. The cases of primary myelodysplastic syndrome corresponding to the group entitled "acquired idiopathic sideroblastic anaemia" had between 21 and 86% ringed sideroblasts; these were also found in 40% (26/65) cases corresponding to refractory anaemia with excess of blasts. Seven of the 22 cases having morphological features of refractory anaemia with excess of blasts in transformation had ringed sideroblasts. It would appear that cases of acquired idiopathic sideroblastic anaemia have at least 20% ringed sideroblasts; they also seem to occur frequently in refractory anaemia with excess of blasts.
为了确定原发性骨髓增生异常综合征中环铁幼粒细胞的患病率及百分比分布，对133例患者的普鲁士蓝染色结果进行了分析。在76例（57%）患者中发现环铁幼粒细胞占细胞总数的比例为1%至86%。对应于“获得性特发性铁粒幼细胞贫血”组的原发性骨髓增生异常综合征患者，其环铁幼粒细胞比例在21%至86%之间；在40%（26/65）的伴有原始细胞增多的难治性贫血患者中也发现了环铁幼粒细胞。在22例具有转化型伴有原始细胞增多的难治性贫血形态学特征的患者中，有7例存在环铁幼粒细胞。看来，获得性特发性铁粒幼细胞贫血患者至少有20%的环铁幼粒细胞；它们似乎也常见于伴有原始细胞增多的难治性贫血患者中。
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