Gorewit R C
J Dairy Sci. 1983 Mar;66(3):624-9. doi: 10.3168/jds.S0022-0302(83)81834-7.
I evaluated effects of ferulic acid on concentrations of endocrine hormones of eight Holstein heifers. Cattle were fitted with indwelling jugular cannulae 24 h before experimentation. After control blood samples were taken, animals were assigned randomly to groups of four and infused with 100 or 500 mg of ferulic acid. Prolactin, growth hormone, luteinizing hormone, and thyroid hormones were measured in sera from blood samples. Blood sampling or ethanol infusion did not affect serum concentrations of prolactin. Serum prolactin was elevated 5 min after infusion of ferulic acid. Peak serum prolactin concentrations were 15 min after 100 mg of ferulic acid and between 10 and 30 min after 500 mg ferulic acid. Prolactin remained high until 120 min post drug administration. Control bleeding and ethanol administration did not alter serum growth hormone concentrations. Serum growth hormone concentrations were elevated slightly by ferulic acid. The increase was 5 min after drug administration. Baseline concentrations were established 60 to 90 min after administration. Ferulic acid did not affect luteinizing hormone or thyroid hormones. Ferulic acid, a constituent of corn and wheat germ, may affect release of pituitary hormones in cattle.
我评估了阿魏酸对八头荷斯坦小母牛内分泌激素浓度的影响。在实验前24小时给牛安装颈静脉留置套管。采集对照血样后，将动物随机分为四组，分别注入100毫克或500毫克阿魏酸。检测血样血清中的催乳素、生长激素、促黄体生成素和甲状腺激素。采血或注入乙醇不影响血清催乳素浓度。注入阿魏酸后5分钟血清催乳素升高。注入100毫克阿魏酸后15分钟血清催乳素浓度达到峰值，注入500毫克阿魏酸后10至30分钟达到峰值。给药后120分钟内催乳素一直保持在较高水平。对照采血和给予乙醇不改变血清生长激素浓度。阿魏酸使血清生长激素浓度略有升高。给药后5分钟出现升高。给药后60至90分钟确立基线浓度。阿魏酸不影响促黄体生成素或甲状腺激素。阿魏酸是玉米和小麦胚芽的一种成分，可能会影响牛垂体激素的释放。
