Novey H S, Fairshter R D, Salness K, Simon R A, Curd J G
J Allergy Clin Immunol. 1983 May;71(5):498-504. doi: 10.1016/0091-6749(83)90468-2.
A variety of systemic reactions associated with exercise are increasingly being recognized. We studied an atopic individual whose job-related activities involved strenuous running that often terminated in an episode of syncope and hypotension preceded by cutaneous pruritus, warmth, urticaria, and angioedema. These attacks occurred only after meals, but no foods appeared to elicit symptoms without subsequent exercise. The subject underwent three exercise challenges in the laboratory under the following conditions: (1) fasting state, with heat-dissipating clothing. (2) fasting, with heat-retention clothes, and (3) after a meal. Blood pressure decreases and minimum skin reactivity were observed for (1) and (2), and reproduction of syncope, hypotension, and further cutaneous manifestation were observed only after (3). Venous and arterial plasma determinations for complement activation (C4, C4d, and CH50) and histamine before, during, and after exercise were not abnormal. Although other vasodepressor mediators may have been liberated, at least part of the mechanism for postprandial exercise-related syncope may be attributed to a shift of blood flow to the splanchnic as well as skeletal muscle vasculature.
与运动相关的各种全身反应越来越受到人们的认识。我们研究了一名特应性个体，其与工作相关的活动包括剧烈跑步，跑步常以晕厥和低血压发作告终，发作前有皮肤瘙痒、发热、荨麻疹和血管性水肿。这些发作仅在饭后出现，但没有食物在没有后续运动的情况下似乎会引发症状。该受试者在实验室中在以下条件下进行了三次运动激发试验：（1）禁食状态，穿着散热衣物。（2）禁食，穿着保暖衣物，以及（3）饭后。观察到（1）和（2）出现血压下降和最低皮肤反应性，仅在（3）之后观察到晕厥、低血压和进一步皮肤表现的重现。运动前、运动期间和运动后静脉和动脉血浆中补体激活（C4、C4d和CH50）和组胺的测定均无异常。尽管可能释放了其他血管舒张性介质，但餐后运动相关晕厥的至少部分机制可能归因于血流向内脏以及骨骼肌血管系统的转移。
