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泰梅尔半岛原住民群体中的免疫球蛋白同种异型

Immunoglobulin allotypes in aboriginal populations of the Taimir Peninsula.

作者信息

Osipova L P, Sukernik R I

出版信息

J Immunogenet. 1983 Feb;10(1):11-6. doi: 10.1111/j.1744-313x.1983.tb01011.x.

DOI:10.1111/j.1744-313x.1983.tb01011.x
PMID:6841979
Abstract

Serum blood samples from 563 of the total 700 Nganasans, members of the isolate in the northern-most part of Siberia were tested for G1m (z,a,x,f), G2m (n), G3m (g,b0,b1,b3,b5,s,t), and Km (1) allotypic determinants. Additionally, 78 Yenisey Samoyeds (Entsi) who are the Nganasan's western neighbours were studied. Both populations are remarkable for high frequency of 'Northern Oriental' Gm (za;..;b0b3b5st) which appears to be the most frequent haplotype in the Nganasans (0 . 486), and is the second frequent in Yenisey Samoyeds (0 . 276). The Gm (f;b) generalized haplotype which used to be considered as an indicator of Caucasian gene flow occurred in the Nganasans in the very low frequency of 0 . 008, versus 0 . 045 revealed in adjoining Yenisey Samoyeds. Both populations also differ in the frequency of Km1 which is two times lower in the Nganasans (0 . 048), than in Yenisey Samoyeds (0 . 103). When segregation ratios for the Gm locus were inspected in 67 Nganasan families, no apparent deviations from Mendelian expectations, and no recombinant phenotypes were observed.

摘要

对来自700名涅涅茨人(西伯利亚最北部与世隔绝的族群)中563人的血清血样进行了G1m(z,a,x,f)、G2m(n)、G3m(g,b0,b1,b3,b5,s,t)和Km(1)等位基因决定簇检测。此外,还研究了作为涅涅茨人西部邻居的78名叶尼塞萨摩耶人(恩齐人)。这两个人群都以高频出现“北方东方人”Gm(za;..;b0b3b5st)为显著特征,该单倍型在涅涅茨人中似乎是最常见的(0.486),在叶尼塞萨摩耶人中是第二常见的(0.276)。过去被视为高加索基因流动指标的Gm(f;b)广义单倍型在涅涅茨人中出现的频率极低,为0.008,而在相邻的叶尼塞萨摩耶人中为0.045。这两个人群在Km1的频率上也存在差异——涅涅茨人中的频率(0.048)比叶尼塞萨摩耶人中的频率(0.103)低两倍。在67个涅涅茨人家庭中检查Gm位点的分离比率时,未观察到明显偏离孟德尔预期的情况,也未观察到重组表型。

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mtDNA variation of aboriginal Siberians reveals distinct genetic affinities with Native Americans.西伯利亚原住民的线粒体DNA变异揭示了与美洲原住民独特的遗传亲缘关系。
Am J Hum Genet. 1993 Sep;53(3):591-608.
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