Gerber A U, Craig W A, Brugger H P, Feller C, Vastola A P, Brandel J
J Infect Dis. 1983 May;147(5):910-7. doi: 10.1093/infdis/147.5.910.
The influence of dosing intervals on the activity of gentamicin and ticarcillin against Pseudomonas aeruginosa was studied in vivo. Granulocytopenic mice infected with P. aeruginosa in the thigh muscle were treated with 1-hr or 3-hr injections of gentamicin, ticarcillin, or gentamicin-ticarcillin. Plasma pharmacokinetics of the drugs were correlated with antibacterial activity. Gentamicin injected every 1 hr tended to be less active than gentamicin injected at longer intervals. In contrast, ticarcillin given every 1 hr was significantly more efficacious than equivalent total doses injected every 3 hr. The dosing schedule of gentamicin-ticarcillin was again important for ticarcillin but did not appreciably affect the antibacterial activity of gentamicin. Thus, antimicrobial chemotherapy of P. aeruginosa infections in the granulocytopenic host might be improved by administering ticarcillin rather than gentamicin as a constant infusion.
在体内研究了给药间隔对庆大霉素和替卡西林抗铜绿假单胞菌活性的影响。用铜绿假单胞菌感染大腿肌肉的粒细胞减少小鼠，分别给予1小时或3小时注射庆大霉素、替卡西林或庆大霉素-替卡西林。药物的血浆药代动力学与抗菌活性相关。每1小时注射一次的庆大霉素活性往往低于间隔较长时间注射的庆大霉素。相比之下，每1小时给予的替卡西林比每3小时注射同等总剂量的替卡西林显著更有效。庆大霉素-替卡西林的给药方案对替卡西林仍然很重要，但对庆大霉素的抗菌活性没有明显影响。因此，通过持续输注给予替卡西林而非庆大霉素，粒细胞减少宿主中铜绿假单胞菌感染的抗菌化疗可能会得到改善。
