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1
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Impact of dosing intervals on activity of gentamicin and ticarcillin against Pseudomonas aeruginosa in granulocytopenic mice.给药间隔对庆大霉素和替卡西林在粒细胞减少小鼠中抗铜绿假单胞菌活性的影响。
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4
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Treatment of Pseudomonas keratitis in the rabbit with antibiotic-steroid combinations.用抗生素-类固醇联合制剂治疗兔铜绿假单胞菌性角膜炎。
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6
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8
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引用本文的文献

1
Ticarcillin: a review of its pharmacological properties and therapeutic efficacy.替卡西林:其药理特性与治疗效果综述
Drugs. 1980 Nov;20(5):325-52. doi: 10.2165/00003495-198020050-00001.

本文引用的文献

1
In vitro studies of alpha-carboxyl-3-thienylmethyl penicillin, a new semisynthetic penicillin.新型半合成青霉素α-羧基-3-噻吩甲基青霉素的体外研究
Appl Microbiol. 1971 Jan;21(1):61-5. doi: 10.1128/am.21.1.61-65.1971.
2
Administration of ticarcillin to patients with severe renal failure.替卡西林用于严重肾衰竭患者的给药。
Chemotherapy. 1974;20(6):339-41. doi: 10.1159/000221824.
3
Clinical and laboratory investigations on ticarcillin, an anti-pseudomonal antibiotic.替卡西林(一种抗假单胞菌抗生素)的临床与实验室研究。
Chemotherapy. 1974;20(1):45-51. doi: 10.1159/000221790.
4
Activity of carbenicillin and ticarcillin against Pseudomonas aeruginosa compared by paired in vitro tests.通过配对体外试验比较羧苄西林和替卡西林对铜绿假单胞菌的活性。
Infection. 1974;2(1):12-4. doi: 10.1007/BF01642217.
5
Penicillin-tobramycin synergism against enterococci: a comparison with penicillin and gentamicin.青霉素与妥布霉素对肠球菌的协同作用:与青霉素和庆大霉素的比较。
Antimicrob Agents Chemother. 1973 Apr;3(4):526-9. doi: 10.1128/AAC.3.4.526.
6
The effect of tobramycin on gentamicin-resistant strains in Pseudomonas keratitis.妥布霉素对铜绿假单胞菌性角膜炎中庆大霉素耐药菌株的作用。
Am J Ophthalmol. 1974 Apr;77(4):583-8. doi: 10.1016/0002-9394(74)90475-9.
7
Comparative in vitro activity and clinical pharmacology of ticarcillin and carbenicillin.替卡西林和羧苄西林的体外活性及临床药理学比较
Antimicrob Agents Chemother. 1975 Oct;8(4):457-62. doi: 10.1128/AAC.8.4.457.
8
Hospital Pseudomonas aeruginosa: surveillance of resistance to gentamicin and transfer of aminoglycoside R factor.医院铜绿假单胞菌:对庆大霉素耐药性及氨基糖苷类R因子转移的监测
Antimicrob Agents Chemother. 1975 Oct;8(4):415-20. doi: 10.1128/AAC.8.4.415.

替卡西林治疗实验性铜绿假单胞菌角膜炎

Ticarcillin in the treatment of experimental pseudomonas keratitis.

作者信息

Ahmad A, Smolin G, Okumoto M, Ohno S

出版信息

Br J Ophthalmol. 1977 Feb;61(2):92-5. doi: 10.1136/bjo.61.2.92.

DOI:10.1136/bjo.61.2.92
PMID:843516
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1042888/
Abstract

In rabbits with experimental Pseudomonas aeruginosa keratitis the subconjunctival administration of either ticarcillin or gentamicin significantly ameliorated the keratitis and reduced the number of organisms to be found in the cornea. The use of these drugs in combination had an additive effect in vitro studies and a significantly more beneficial effect on the clinical disease than the use of either drug alone.

摘要

在患有实验性铜绿假单胞菌角膜炎的兔子中,结膜下注射替卡西林或庆大霉素均可显著改善角膜炎,并减少角膜中的细菌数量。在体外研究中,联合使用这些药物具有相加作用,且对临床疾病的治疗效果明显优于单独使用任何一种药物。