Ahmad A, Smolin G, Okumoto M, Ohno S
Br J Ophthalmol. 1977 Feb;61(2):92-5. doi: 10.1136/bjo.61.2.92.
In rabbits with experimental Pseudomonas aeruginosa keratitis the subconjunctival administration of either ticarcillin or gentamicin significantly ameliorated the keratitis and reduced the number of organisms to be found in the cornea. The use of these drugs in combination had an additive effect in vitro studies and a significantly more beneficial effect on the clinical disease than the use of either drug alone.
在患有实验性铜绿假单胞菌角膜炎的兔子中,结膜下注射替卡西林或庆大霉素均可显著改善角膜炎,并减少角膜中的细菌数量。在体外研究中,联合使用这些药物具有相加作用,且对临床疾病的治疗效果明显优于单独使用任何一种药物。