Skinhøj P, Aldershvile J, Kjersem M, Black F
J Med Virol. 1983;11(2):125-9. doi: 10.1002/jmv.1890110206.
The occurrence of hepatitis B infection as measured by sensitive serological tests for HBsAg, HBeAg and hepatitis B-specific antibodies was studied in Vietnamese refugee families. HBsAg was found in 10% of 301 children studied. Totally 74% of all HBsAg-positive children had an HBsAg-positive mother or father and an additional 7% had a positive sibling. The distribution of these cases indicated that the risk of HBs-antigenemia was increased 11-fold for those who had an HBsAg-positive mother compared with all other children. The presence of HBeAg in the HBsAg-positive parents was associated with a threefold higher risk of HBs-antigenemia in children as compared with the presence of anti-HBe. It was thus documented that HBV in this population is spread primarily by intrafamilial routes and prophylactic measures within risk families should largely be able to control the appearance of new HBsAg carriers.
通过对乙肝表面抗原（HBsAg）、乙肝e抗原（HBeAg）和乙肝特异性抗体进行敏感的血清学检测，研究了越南难民家庭中乙肝感染的发生情况。在301名接受研究的儿童中，10%的儿童检测出HBsAg阳性。在所有HBsAg阳性儿童中，74%的儿童父母一方HBsAg呈阳性，另有7%的儿童兄弟姐妹HBsAg呈阳性。这些病例的分布表明，与所有其他儿童相比，母亲HBsAg呈阳性的儿童发生乙肝抗原血症的风险增加了11倍。与乙肝e抗体（anti-HBe）阳性的父母相比，HBsAg阳性父母体内存在HBeAg会使儿童发生乙肝抗原血症的风险增加两倍。因此有证据表明，该人群中的乙肝病毒主要通过家庭内部途径传播，在有风险的家庭中采取预防措施应能在很大程度上控制新的HBsAg携带者的出现。
