Locniskar M, Nauss K M, Newberne P M
J Nutr. 1983 May;113(5):951-61. doi: 10.1093/jn/113.5.951.
The effect of the quality and quantity of dietary fats on the morphology and function of the immune system of Sprague-Dawley rats fed either 5% mixed fat, 24% saturated fat, 24% polyunsaturated fat, or 24% partially saturated fat was examined. After 2.5 months of dietary treatment high fat groups showed evidence of splenic hyperplasia, however, no consistent morphologic changes were seen in the mesenteric lymph nodes (MLN). Splenocytes from rats fed the 24% polyunsaturated fat diet were cultured in fetal bovine serum (FBS) and had a depressed lymphocyte transformation response, which persisted after 5 months of dietary treatment. Supplementing the culture medium with 10% rat serum altered the transformation response profile, but high fat serum did not have an immunosuppressive effect. MLN lymphocytes from rats fed the 24% partially saturated diet for 2.5 months had an enhanced response to concanavalin A; at five months the response was elevated in the groups fed saturated as well as partially saturated fat diets. These results suggest that the modulating effect of fat on the immune system depends on the duration of feeding, the type of fat consumed and the organ examined.
研究了膳食脂肪的质量和数量对喂食5%混合脂肪、24%饱和脂肪、24%多不饱和脂肪或24%部分饱和脂肪的斯普拉格-道利大鼠免疫系统形态和功能的影响。经过2.5个月的膳食处理后，高脂肪组出现脾脏增生迹象，然而，在肠系膜淋巴结（MLN）中未观察到一致的形态学变化。喂食24%多不饱和脂肪饮食的大鼠的脾细胞在胎牛血清（FBS）中培养，其淋巴细胞转化反应受到抑制，这种抑制在膳食处理5个月后仍然存在。向培养基中添加10%的大鼠血清改变了转化反应模式，但高脂肪血清没有免疫抑制作用。喂食24%部分饱和饮食2.5个月的大鼠的MLN淋巴细胞对伴刀豆球蛋白A的反应增强；在5个月时，喂食饱和脂肪和部分饱和脂肪饮食的组中反应升高。这些结果表明，脂肪对免疫系统的调节作用取决于喂食时间、摄入脂肪的类型以及所检查的器官。
