de Vries E, Van Buijsen A C, Van der Weij J P, Haasnoot C J, Meijer C J, Cats A
J Rheumatol. 1983 Feb;10(1):12-8.
A morphometric analysis of lymphocytes from the peripheral blood and the synovial fluid (SF) of patients with rheumatoid arthritis (RA) was based on a determination of the nuclear contour index (NCI = perimeter divided by the square root of the area of the nucleus). Use of this method showed that a particular type of lymphocyte, the cerebriform mononuclear cell (CMC), occurred in higher percentages in the SF than in the peripheral blood of patients with RA. The mean NCI of the lymphocytes (non-CMC) was also higher in the SF. These findings indicate that lymphocytes in the inflammatory compartment are morphologically altered, compared to the corresponding cells in the peripheral blood of the same patients, the change probably expressing an alteration in functional status.
对类风湿性关节炎（RA）患者外周血和滑液（SF）中的淋巴细胞进行形态计量分析，是基于对核轮廓指数（NCI = 周长除以细胞核面积的平方根）的测定。使用这种方法表明，一种特殊类型的淋巴细胞，即脑形单核细胞（CMC），在RA患者的滑液中出现的百分比高于外周血。滑液中淋巴细胞（非CMC）的平均NCI也更高。这些发现表明，与同一患者外周血中的相应细胞相比，炎症部位的淋巴细胞在形态上发生了改变，这种变化可能反映了功能状态的改变。
