Proctor K G, Howards S S
J Urol. 1983 Apr;129(4):837-8. doi: 10.1016/s0022-5347(17)52390-3.
A double-blind controlled study of the effects on semen quality of 4 alpha-adrenergic agents with and without antihistamines was conducted in a patient who had failure of emission secondary to retroperitoneal lymphadenectomy for testis cancer. No other controlled studies are available. All of the alpha-adrenergic drugs allowed the patient to produce an ejaculate. The effects were similar. The addition of antihistamine did not improve the semen quality. Four days of treatment were consistently more effective than a single dose, especially for sperm motility. A pregnancy resulted. It is concluded that long-term treatment with alpha-adrenergic drugs is indicated in men with failure of emission secondary to retroperitoneal lymphadenectomy.
在一名因睾丸癌行腹膜后淋巴结清扫术继发射精障碍的患者中，开展了一项双盲对照研究，观察4种α-肾上腺素能药物在联合或不联合抗组胺药情况下对精液质量的影响。尚无其他对照研究。所有α-肾上腺素能药物均使该患者能够射出精液。效果相似。添加抗组胺药并未改善精液质量。连续4天治疗始终比单次给药更有效，尤其是对精子活力而言。患者成功受孕。结论是，对于因腹膜后淋巴结清扫术继发射精障碍的男性，建议使用α-肾上腺素能药物进行长期治疗。
