Rosen P
Med Hypotheses. 1983 Jan;10(1):33-5. doi: 10.1016/0306-9877(83)90049-x.
A review of the literature shows that x-ray induced lung adenomas in mice, breast adenomas in rats and thyroid adenomas in rats show the same approximate dependence for number of tumors vs dose. It is hypothesized that these benign tumors are due to cell proliferation. The controls of the G1 stage of the cell cycle have been affected by mutation, such that the time in G1 is very small. In carcinogenesis it is M that is affected.
文献综述表明，X射线诱导的小鼠肺腺瘤、大鼠乳腺腺瘤和大鼠甲状腺腺瘤，在肿瘤数量与剂量的关系上表现出大致相同的依赖性。据推测，这些良性肿瘤是由细胞增殖引起的。细胞周期G1期的调控受到了突变的影响，使得G1期的时间非常短。在致癌过程中，受到影响的是M期。
