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与钙剥夺相比，多胺合成抑制剂会使细胞在G1期的更早阶段停滞。

An inhibitor of polyamine synthesis arrests cells at an earlier stage of G1 than does calcium deprivation.

作者信息

Cheetham B F

出版信息

Mol Cell Biol. 1983 Mar;3(3):480-3. doi: 10.1128/mcb.3.3.480-483.1983.

DOI:10.1128/mcb.3.3.480-483.1983
PMID:6843551
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC368558/
Abstract

Methylglyoxal bis(guanylhydrazone) completely inhibits the induction of thymidine kinase after serum stimulation of quiescent fibroblasts only if added within 3 h after serum, whereas calcium deprivation blocks this induction up to 12 h after serum stimulation. Experiments in which one of these blocks was imposed as the other was released confirmed that cells blocked by methylglyoxal bis(guanylhydrazone) are arrested at an earlier stage in G1 than cells blocked by calcium deprivation.

摘要

双脒腙只有在血清刺激静止成纤维细胞后3小时内添加，才能完全抑制胸苷激酶的诱导，而钙缺乏在血清刺激后12小时内都能阻断这种诱导。在一个阻断因素施加而另一个阻断因素解除的实验中，证实被双脒腙阻断的细胞在G1期比被钙缺乏阻断的细胞更早被阻滞。

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An inhibitor of polyamine synthesis arrests cells at an earlier stage of G1 than does calcium deprivation.与钙剥夺相比，多胺合成抑制剂会使细胞在G1期的更早阶段停滞。
Mol Cell Biol. 1983 Mar;3(3):480-3. doi: 10.1128/mcb.3.3.480-483.1983.
2
Dissociation of the early antiproliferative action of methylglyoxal bis(guanylhydrazone) from polyamine depletion. A comparison of the effects of DL-alpha-difluromethyl ormithine and methylglyoxal bis(guanylhydrazone) on the growth of human fibroblasts.甲基乙二醛双（脒腙）早期抗增殖作用与多胺耗竭的解离。DL-α-二氟甲基鸟氨酸和甲基乙二醛双（脒腙）对人成纤维细胞生长影响的比较。
FEBS Lett. 1979 Jan 1;97(1):9-14. doi: 10.1016/0014-5793(79)80040-x.
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Suppression of phytohemagglutinin-induction of thymidine uptake in guinea pig lymphocytes by methylglyoxal bis(guanylhydrazone) treatment.用丙酮醛双（脒腙）处理对豚鼠淋巴细胞中植物血凝素诱导的胸苷摄取的抑制作用。
Biochim Biophys Acta. 1977 Oct 18;478(4):417-27. doi: 10.1016/0005-2787(77)90097-1.
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A biochemical investigation of the adenovirus-induced G1 to S phase progression: thymidine kinase, ornithine decarboxylase, and inhibitors of polyamine biosynthesis.腺病毒诱导的G1期至S期进程的生化研究：胸苷激酶、鸟氨酸脱羧酶及多胺生物合成抑制剂
J Cell Physiol. 1982 Feb;110(2):114-22. doi: 10.1002/jcp.1041100203.
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Cancer Res. 1977 Sep;37(9):3169-72.
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Physiological effects in bovine lymphocytes of inhibiting polyamine synthesis with ethylglyoxal bis(guanylhydrazone).乙二醛双（脒腙）抑制牛淋巴细胞多胺合成的生理效应
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Suppression of the formation of polyamines and macromolecules by DL-alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) in phytohaemagglutinin-activated human lymphocytes.DL-α-二氟甲基鸟氨酸和甲基乙二醛双（脒腙）对植物血凝素激活的人淋巴细胞中多胺和大分子形成的抑制作用
Biochem J. 1979 Jan 15;178(1):109-17. doi: 10.1042/bj1780109.
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Ethylglyoxal bis(guanylhydrazone) as an inhibitor of polyamine biosynthesis in L1210 leukemia cells.乙二醛双（脒腙）作为L1210白血病细胞中多胺生物合成的抑制剂。
Biochim Biophys Acta. 1984 Apr 16;803(4):331-7. doi: 10.1016/0167-4889(84)90125-3.
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Diminished excretion of polyamines from BHK-21/C13 cells exposed to methylglyoxal bis(guanylhydrazone).暴露于甲基乙二醛双（胍腙）的BHK-21/C13细胞中多胺排泄减少。
Biochem J. 1978 Jul 15;174(1):349-52. doi: 10.1042/bj1740349.

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本文引用的文献

1
Genetic Control of the Cell Division Cycle in Yeast: V. Genetic Analysis of cdc Mutants.酵母细胞分裂周期的遗传控制：V. cdc 突变体的遗传分析。
Genetics. 1973 Jun;74(2):267-86. doi: 10.1093/genetics/74.2.267.
2
Related effects of calcium and serum on the G1 phase of the human W138 fibroblast.钙和血清对人W138成纤维细胞G1期的相关影响。
J Cell Physiol. 1980 Jul;104(1):97-103. doi: 10.1002/jcp.1041040113.
3
A biochemical investigation of the adenovirus-induced G1 to S phase progression: thymidine kinase, ornithine decarboxylase, and inhibitors of polyamine biosynthesis.腺病毒诱导的G1期至S期进程的生化研究：胸苷激酶、鸟氨酸脱羧酶及多胺生物合成抑制剂
J Cell Physiol. 1982 Feb;110(2):114-22. doi: 10.1002/jcp.1041100203.
4
Methyl glyoxal bis(guanylhydrazone) as a potent inhibitor of mammalian and yeast S-adenosylmethionine decarboxylases.甲基乙二醛双（胍基腙）作为哺乳动物和酵母S-腺苷甲硫氨酸脱羧酶的有效抑制剂。
Biochem Biophys Res Commun. 1972 Jan 14;46(1):288-95. doi: 10.1016/0006-291x(72)90661-4.
5
A restriction point for control of normal animal cell proliferation.正常动物细胞增殖控制的一个限制点。
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1286-90. doi: 10.1073/pnas.71.4.1286.
6
Potential inhibitors of polyamine biosynthesis. 2. alpha-Alkyl- and benzyl-(+/-)-ornithine.多胺生物合成的潜在抑制剂。2. α-烷基和苄基-(±)-鸟氨酸。
J Med Chem. 1975 Jun;18(6):600-4. doi: 10.1021/jm00240a015.
7
The use of conditional lethal cell cycle mutants for temporal and functional sequence mapping of cell cycle events.利用条件致死性细胞周期突变体进行细胞周期事件的时间和功能序列图谱绘制。
J Cell Physiol. 1978 Jun;95(3):393-405. doi: 10.1002/jcp.1040950318.