与钙剥夺相比，多胺合成抑制剂会使细胞在G1期的更早阶段停滞。
An inhibitor of polyamine synthesis arrests cells at an earlier stage of G1 than does calcium deprivation.
作者信息
Cheetham B F
出版信息
Mol Cell Biol. 1983 Mar;3(3):480-3. doi: 10.1128/mcb.3.3.480-483.1983.
Abstract
Methylglyoxal bis(guanylhydrazone) completely inhibits the induction of thymidine kinase after serum stimulation of quiescent fibroblasts only if added within 3 h after serum, whereas calcium deprivation blocks this induction up to 12 h after serum stimulation. Experiments in which one of these blocks was imposed as the other was released confirmed that cells blocked by methylglyoxal bis(guanylhydrazone) are arrested at an earlier stage in G1 than cells blocked by calcium deprivation.
摘要
双脒腙只有在血清刺激静止成纤维细胞后3小时内添加，才能完全抑制胸苷激酶的诱导，而钙缺乏在血清刺激后12小时内都能阻断这种诱导。在一个阻断因素施加而另一个阻断因素解除的实验中，证实被双脒腙阻断的细胞在G1期比被钙缺乏阻断的细胞更早被阻滞。
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