暴露于甲基乙二醛双（胍腙）的BHK-21/C13细胞中多胺排泄减少。
Diminished excretion of polyamines from BHK-21/C13 cells exposed to methylglyoxal bis(guanylhydrazone).
作者信息
Melvin M A, Keir H M
出版信息
Biochem J. 1978 Jul 15;174(1):349-52. doi: 10.1042/bj1740349.
Abstract
Methylglyoxal bis(guanylhydrazone) (1,1'-[methylethanediylidine)dinitrilo]diguanidine) inhibited the growth of BHK-21/C13 cells in monolayer cultures. Accumulation of spermidine and spermine was inhibited, whereas the accumulation of putrescine was increased. The intracellular spermidine/spermine molar ratio decreased conly slightly after exposure of the cells to 20 micrometer-methylglyoxal bis(guanylhydrazone) for 1 day. Cells incubated in the presence of the drug released less polyamine into the culture medium that did control cells, the polyamine released consisting almost exclusively of spermidine, both free and as a conjugated form.
摘要
甲基乙二醛双（胍腙）（1,1'-[甲基乙二亚基]二亚氨基双胍）抑制单层培养的BHK-21/C13细胞的生长。亚精胺和精胺的积累受到抑制，而腐胺的积累增加。细胞在20微摩尔甲基乙二醛双（胍腙）中培养1天后，细胞内亚精胺/精胺摩尔比仅略有下降。在药物存在下培养的细胞向培养基中释放的多胺比对照细胞少，释放的多胺几乎完全由亚精胺组成，包括游离形式和结合形式。
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2
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3
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Fed Proc. 1970 Jul-Aug;29(4):1563-7.
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