Morphine blocks the increase in acid phosphatase in the substantia gelatinosa during pain.
作者信息
Hershberger E A, Kantner R M, Kirby M L
出版信息
Neurosci Lett. 1983 Mar 14;35(3):307-10. doi: 10.1016/0304-3940(83)90335-x.
PMID:6843906
Abstract
Acid phosphatase activity in the rat substantia gelatinosa has been shown to increase in response to a formalin-induced painful stimulus. In the rat the substantia gelatinosa is the location of the first synapse in the pain pathway. One site of morphine's analgesic effect is at this first synapse. The present study shows that morphine blocks the previously observed increase in acid phosphatase activity during a painful stimulus. Naloxone antagonizes the morphine effect. These results point to a possible functional role of acid phosphatase in the afferent transmission of pain signals.
摘要
相似文献
1
Morphine blocks the increase in acid phosphatase in the substantia gelatinosa during pain.
Neurosci Lett. 1983 Mar 14;35(3):307-10. doi: 10.1016/0304-3940(83)90335-x.
2
Changes in acid phosphatase activity in the substantia gelatinosa in response to pain.胶状质中酸性磷酸酶活性对疼痛的反应变化。
Brain Res. 1982 Apr 29;238(2):451-6. doi: 10.1016/0006-8993(82)90122-6.
3
Appearance of acid phosphatase in neonatal rat substantia gelatinosa.新生大鼠脊髓胶状质中酸性磷酸酶的出现
Exp Brain Res. 1981;41(3-4):411-3. doi: 10.1007/BF00238899.
4
5
[Ultrastructural localization of acid phosphatase in the substantia gelatinosa of rats].[大鼠脊髓胶状质中酸性磷酸酶的超微结构定位]
Verh Anat Ges. 1977(71 Pt 2):1041-3.
6
Representation of cutaneous afferents by fluoride-resistant acid phosphatase (FRAP)-active terminals in the rat substantia gelatinosa rolandi.大鼠胶状质中抗氟酸性磷酸酶（FRAP）活性终末对皮肤传入神经的代表。
Acta Neurol Scand. 1976 Mar;53(3):217-25. doi: 10.1111/j.1600-0404.1976.tb04340.x.
7
Actions of morphine and met-enkephalin-amide on nociceptor driven neurones in substantia gelatinosa and deeper dorsal horn.吗啡和甲硫氨酸脑啡肽酰胺对胶状质和背角深层中伤害感受器驱动神经元的作用。
Neuropharmacology. 1983 Jan;22(1):119-22. doi: 10.1016/0028-3908(83)90270-8.
8
Morphine, enkephalin and the substantia gelatinosa.
Nature. 1976 Dec 2;264(5585):456-8. doi: 10.1038/264456a0.
9
Evidence that the opiate receptors of the substantia gelatinosa contribute to the depression, by intravenous morphine, of the spinal transmission of impulses in unmyelinated primary afferents.有证据表明，脊髓背角胶状质中的阿片受体参与了静脉注射吗啡对无髓初级传入纤维冲动脊髓传导的抑制作用。
Brain Res. 1981 Feb 23;207(1):223-8. doi: 10.1016/0006-8993(81)90698-3.
10
Fluoride-resistant acid phosphatase (FRAP)-positive afferent terminals make synaptic contact with interneuronal soma in the substantia gelatinosa of the mouse spinal dorsal horn.耐氟酸性磷酸酶（FRAP）阳性传入终末与小鼠脊髓背角胶状质中神经元间的胞体形成突触联系。
Okajimas Folia Anat Jpn. 1997 Aug;74(2-3):109-13. doi: 10.2535/ofaj1936.74.2-3_109.
引用本文的文献
1
Enzyme-cytochemical study of small ganglion cells in experimental thiamine deficiency: concerning the pain mechanism.实验性硫胺素缺乏时小神经节细胞的酶细胞化学研究：关于疼痛机制
Acta Neuropathol. 1991;81(4):396-400. doi: 10.1007/BF00293460.
Zotero 插件