Abdel Karim F W, Ayash R E, Allam C, Salem P A
Oncology. 1983;40(3):174-6. doi: 10.1159/000225719.
Interstitial pulmonary fibrosis is described in a 26-year-old woman with malignant lymphoma after prolonged intake of cyclophosphamide. Cyclophosphamide was given over a period of 13 years in an oral daily dose of 50-100 mg. Lung biopsy revealed extensive fibrosis with no evidence of malignancy or infection. Cyclophosphamide is considered the most likely cause of pulmonary fibrosis in this patient.
一名26岁患有恶性淋巴瘤的女性在长期服用环磷酰胺后出现间质性肺纤维化。环磷酰胺连续服用了13年，每日口服剂量为50 - 100毫克。肺活检显示广泛纤维化，无恶性肿瘤或感染迹象。环磷酰胺被认为是该患者肺纤维化最可能的病因。
