Mark G J, Lehimgar-Zadeh A, Ragsdale B D
Thorax. 1978 Feb;33(1):89-93. doi: 10.1136/thx.33.1.89.
Cyclophosphamide can rarely cause interstitial pneumonitis and fibrosis. Although it has been reported previously in patients being treated for lymphoma, it occurred in this case in a man under treatment for glomerulonephritis. The temporal sequence of the respiratory insufficiency and the histopathology, when compared to the previous examples in the literature, suggest that cyclophosphamide was aetiologically responsible for the lung disease. There may be an interval of one or more months after discontinuation of cyclophosphamide therapy before clinical or radiological improvement occurs.
环磷酰胺极少会引起间质性肺炎和肺纤维化。虽然此前已有在淋巴瘤治疗患者中出现这种情况的报道，但该病例发生在一名正在接受肾小球肾炎治疗的男性身上。与文献中之前的例子相比，呼吸功能不全的时间顺序和组织病理学表现表明，环磷酰胺是导致该肺部疾病的病因。在停用环磷酰胺治疗后，可能会间隔一个或多个月才出现临床或影像学改善。
