Reif A E
Oncology. 1983;40(3):210-7. doi: 10.1159/000225728.
Susceptibility to cancer implies being easily affected by carcinogen, as well as having an overt spontaneous incidence of cancer. The susceptibility of a population to the development of fatal cancer of a given organ can be represented by a frequency distribution. This distribution depends both upon the genetic susceptibility of the population and upon all environmental carcinogens that have impinged on that population. The method for construction of such a susceptibility distribution has been simplified and applied to experimental data on bone tumor induction with 90Sr in mice, and to bone tumor mortality and prostate cancer mortality in man. The relative susceptibilities of different human organs to the development of fatal tumors can be defined in terms of the spontaneous tumor mortalities.
癌症易感性意味着容易受到致癌物的影响，以及有明显的癌症自发发病率。特定器官致命性癌症发生的人群易感性可以用频率分布来表示。这种分布既取决于人群的遗传易感性，也取决于作用于该人群的所有环境致癌物。构建这种易感性分布的方法已经简化，并应用于小鼠中用90Sr诱导骨肿瘤的实验数据，以及人类的骨肿瘤死亡率和前列腺癌死亡率。不同人体器官对致命肿瘤发生的相对易感性可以根据自发肿瘤死亡率来定义。
