Berisha A, Buznikov G A, Mal'chenko L A, Rakić L
Ontogenez. 1983 Mar-Apr;14(2):173-9.
Zu, Cu, Cd, Pb and Hg salts blocked the cleavage divisions in the sea urchin embryos and, in lesser concentrations, affected gastrulation and induced postgastrulation defects. The early embryo- and cytotoxic effects of Zn salts appear to be based on the inhibition of protein synthesis. Unithiol exerted a protective effect. All salts under study inhibited protein synthesis in the Ehrlich's ascite carcinoma and ascite hepatoma 22a cells; unithiol and other suldhydryl compounds exerted in this case a good protective effect against Cd salts only.
锌、铜、镉、铅和汞盐会阻断海胆胚胎的卵裂，浓度较低时会影响原肠胚形成并导致原肠胚形成后出现缺陷。锌盐对早期胚胎的细胞毒性作用似乎基于对蛋白质合成的抑制。二巯丙醇具有保护作用。所有研究的盐类均抑制艾氏腹水癌和腹水型肝癌22a细胞中的蛋白质合成；在此情况下，二巯丙醇和其他巯基化合物仅对镉盐具有良好的保护作用。
