Sloan P J, Beevers D G
Pharmatherapeutica. 1983;3(5):349-53.
Twenty patients with hypertension uncontrolled by existing therapy with two or three antihypertensive agents (a beta-blocker plus a thiazide diuretic in 10 and with the addition of hydralazine or prazosin in the other 10) were studied to assess the effects of additional long-term administration of nifedipine. Eighteen patients received 10 mg nifedipine 3-times daily and 2 received 20 mg twice daily. Patients were followed-up at monthly intervals. The results showed that mean blood pressure levels were reduced at 1 month and adequate control was achieved and maintained in 12 (60%) of the patients. Five of those who continued with the combined treatment remained non-responders and 3 patients had to stop nifedipine because of side-effects (flushing and headaches). Four other patients reported similar side-effects. No changes were evident in weight, pulse rate or the haematological and biochemical parameters studied.
对20例高血压患者进行了研究，这些患者使用两种或三种抗高血压药物进行现有治疗后血压仍未得到控制（10例患者使用β受体阻滞剂加噻嗪类利尿剂，另外10例在此基础上加用肼屈嗪或哌唑嗪），以评估长期额外服用硝苯地平的效果。18例患者每日3次服用10 mg硝苯地平，2例患者每日2次服用20 mg硝苯地平。患者每月随访一次。结果显示，1个月时平均血压水平降低，12例（60%）患者实现并维持了充分的血压控制。继续联合治疗的患者中有5例仍无反应，3例患者因副作用（面部潮红和头痛）不得不停用硝苯地平。另外4例患者也报告了类似的副作用。所研究的体重、脉搏率或血液学和生化参数均无明显变化。
