Ahlers I, Ahlersová E, Smajda B
Physiol Bohemoslov. 1983;32(1):64-72.
Young male Wistar rats of a conventional breed were kept 4 weeks in a separate room with a light: dark regimen of 12:12 h. Some were fed ad libitum (group C, the control), some were meal-fed from 8.30 to 10.30 a.m. (group A) and the others were meal-fed from 8.30 to 10.30 p.m. (group B). When adapted to the nutritional regimen the animals were decapitated at 3-hour intervals, starting at 8 a.m., and their serum and epididymal tissue non-esterified fatty acid values, their serum and liver triacylglycerol and total cholesterol levels and their serum phospholipid concentration were determined. Limitation of the period for which they had access to food at different times of the day significantly synchronized the circadian oscillations of their serum and tissue lipid levels. The most pronounced differences in the form of the antiphase position of the maxima of the curves in groups A and B, or A and C, were recorded in the oscillations of the serum and white adipose non-esterified fatty acid values, in serum triacylglycerol levels and in liver cholesterol levels. It is reasonable to assume that the synchronizing role of timed meal-feeding will be subject to the influence of seasonal factors.
将常规品系的雄性Wistar幼鼠单独饲养在一个房间中4周，房间的光照：黑暗周期为12:12小时。一些幼鼠随意进食（C组，对照组），一些在上午8:30至10:30进食（A组），另一些在晚上8:30至10:30进食（B组）。当适应营养方案后，从上午8点开始，每隔3小时将动物断头，并测定它们的血清和附睾组织非酯化脂肪酸值、血清和肝脏三酰甘油及总胆固醇水平以及血清磷脂浓度。限制它们在一天中不同时间获取食物的时间段，显著同步了它们血清和组织脂质水平的昼夜节律振荡。在血清和白色脂肪非酯化脂肪酸值、血清三酰甘油水平和肝脏胆固醇水平的振荡中，记录到A组和B组或A组和C组曲线最大值的反相位置形式上最明显的差异。有理由认为，定时进餐的同步作用将受到季节因素的影响。
