Oektedalen O, Opstad P K, Schaffalitzky de Muckadell O B, Fausa O, Flaten O
Regul Pept. 1983 Feb;5(3):235-44. doi: 10.1016/0167-0115(83)90254-9.
Twenty young men divided into two groups participated in a five day training course with prolonged and heavy physical exercise, calorie supply deficiency and severe sleep deprivation. Basal acid output (BAO) was measured immediately after the course in seven of ten subjects who were given placebo tablets (placebo group) and in four of ten subjects who had a daily intake of 1 g cimetidine (cimetidine-group) during the course. Median BAO increased 3-fold in the placebo subjects (from 2.7 mmol/h to 8.2 mmol/h) but showed no increase in the cimetidine treated subjects. The median fasting plasma concentrations of secretin increased 2-8-fold during the course. Gastric suction for 1 h or ingestion of cimetidine reduced the plasma concentration of secretin by approx. 50%. Vasoactive intestinal polypeptide (VIP) increased 2-fold and was not influenced by reduction of gastric acid. The placebo group showed a small increase (P less than 0.05) in plasma concentration of gastrin on day two during the course. The study shows a marked hyperchlorhydria which partly explains the fasting hypersecretinemia found during prolonged strain. This strain-induced hyperchlorhydria could be abolished by treatment with the selective H2-receptor antagonist cimetidine.
二十名年轻男性被分成两组，参加了一个为期五天的培训课程，期间进行了长时间的高强度体育锻炼，存在热量供应不足和严重睡眠剥夺的情况。在课程结束后，立即对十名服用安慰剂片的受试者中的七名（安慰剂组）以及在课程期间每天摄入1克西咪替丁的十名受试者中的四名（西咪替丁组）测量基础酸排出量（BAO）。安慰剂组受试者的BAO中位数增加了3倍（从2.7毫摩尔/小时增至8.2毫摩尔/小时），而西咪替丁治疗组的受试者则未增加。在课程期间，促胰液素的空腹血浆浓度中位数增加了2至8倍。持续1小时的胃抽吸或摄入西咪替丁可使促胰液素的血浆浓度降低约50%。血管活性肠肽（VIP）增加了2倍，且不受胃酸减少的影响。安慰剂组在课程第二天时胃泌素血浆浓度有小幅升高（P<0.05）。该研究显示出明显的胃酸过多，这部分解释了在长期应激期间发现的空腹高促胰液素血症。这种应激诱导的胃酸过多可以通过使用选择性H2受体拮抗剂西咪替丁进行治疗而消除。
