Oktedalen O, Opstad P K, Waldum H, Jorde R
Scand J Gastroenterol. 1983 May;18(4):555-60. doi: 10.3109/00365528309181637.
The effect of a prolonged 5-day fast on the blood concentrations of vasoactive intestinal polypeptide (VIP), secretin, human pancreatic polypeptide (hPP), gastrin, and group I pepsinogens (PG I) was studied in 11 healthy subjects. During the fast there was a marked increase in the concentrations of VIP, secretin, and hPP, whereas the rise in the concentrations of gastrin and PG I was less pronounced. Refeeding suppressed the increased concentration of VIP and caused elevated postprandial concentrations of secretin and hPP, whereas starvation did not influence the postprandial release of gastrin and PG I. The study shows that prolonged starvation has a pronounced effect on gut endocrine responses.
在11名健康受试者中研究了为期5天的长期禁食对血管活性肠肽（VIP）、促胰液素、人胰多肽（hPP）、胃泌素和I组胃蛋白酶原（PG I）血液浓度的影响。禁食期间，VIP、促胰液素和hPP的浓度显著升高，而胃泌素和PG I浓度的升高则不太明显。重新进食抑制了VIP浓度的升高，并导致餐后促胰液素和hPP浓度升高，而饥饿对餐后胃泌素和PG I的释放没有影响。该研究表明，长期饥饿对肠道内分泌反应有显著影响。
