Oektedalen O, Opstad P K, Schaffalitzky de Muckadell O B
Regul Pept. 1982 Sep;4(4):213-9. doi: 10.1016/0167-0115(82)90113-6.
The plasma concentration of secretin was measured during a 5-day military training course comprising prolonged physical exercise (35% of max O2 uptake), severe caloric deficiency (approx. 35700 kJ/24 h) and sleep deprivation (only 2 h of sleep as a total during 5 days). 24 subjects were divided into 3 groups, one group was compensated for the caloric deficiency and another group was partly compensated for the sleep deprivation. The results showed that the fasting plasma secretin increased 3-6-fold (from 1.8-3.7 to 13.3-19.1 pmol/l) during the course with small differences in increase between the groups. Ingestion of a mixed meal reduced the fasting plasma secretin by about 40% during the course, while oral glucose reduced the plasma secretin to the concentrations found in the control experiment. The study shows that plasma secretin is increased when man is exposed to prolonged multifactorial stress. Additional food or sleep appears to have small influence on the fasting plasma secretin, but after giving a meal or oral glucose solution the plasma secretin decreases rapidly.
在一个为期5天的军事训练课程中，对促胰液素的血浆浓度进行了测量。该课程包括长时间的体育锻炼（最大摄氧量的35%）、严重的热量不足（约35700千焦/24小时）和睡眠剥夺（5天内总共只睡2小时）。24名受试者被分为3组，一组补充热量不足，另一组部分补偿睡眠剥夺。结果显示，在课程期间，空腹血浆促胰液素增加了3至6倍（从1.8 - 3.7皮摩尔/升增至13.3 - 19.1皮摩尔/升），各组之间的增加差异很小。在课程期间，摄入混合餐使空腹血浆促胰液素降低了约40%，而口服葡萄糖则使血浆促胰液素降至对照实验中的浓度。该研究表明，当人暴露于长时间的多因素应激时，血浆促胰液素会增加。额外的食物或睡眠似乎对空腹血浆促胰液素影响较小，但进食或给予口服葡萄糖溶液后，血浆促胰液素会迅速下降。
