Ueno K, Shimoto Y, Yokoyama A, Kitagawa H, Takeno S, Sakai T, Saito H
Res Commun Chem Pathol Pharmacol. 1983 Feb;39(2):179-88.
Alleviation of aspirin-induced fetotoxicity by calcium was investigated in rats. ASA (500 mg/kg s.c.) decreased the plasma Ca level in pregnant rats and that in the feto-placenta units. 0.05 M CaCl2 given to dams as tap water on days 8 through 20 of gestation inhibited ASA-induced hypocalcemic effect in maternal plasma. Tap water of 0.002-0.05 M CaCl2, Ca(OH)2 and Ca-lactate on days 8 through 20 of gestation alleviated malformations elicited by the administration of ASA (500 mg/kg s.c.) on the 11th day of gestation resulting in a decrease in the fetotoxicity in rats.
在大鼠中研究了钙对阿司匹林诱导的胎儿毒性的缓解作用。阿司匹林（500毫克/千克，皮下注射）降低了孕鼠及其胎儿-胎盘单位的血浆钙水平。在妊娠第8至20天，给孕鼠饮用含0.05M氯化钙的自来水，可抑制阿司匹林诱导的母体血浆低钙血症效应。在妊娠第8至20天，饮用含0.002 - 0.05M氯化钙、氢氧化钙和乳酸钙的自来水，可减轻妊娠第11天皮下注射阿司匹林（500毫克/千克）所引发的畸形，从而降低大鼠的胎儿毒性。
