乙酰水杨酸类似物引起的胎儿毒性和低钙血症。

Fetal toxicity and hypocalcemia induced by acetylsalicylic acid analogues.

作者信息

Saito H, Yokoyama A, Takeno S, Sakai T, Ueno K, Masumura H, Kitagawa H

出版信息

Res Commun Chem Pathol Pharmacol. 1982 Nov;38(2):209-20.

Abstract

In the present study, we investigated a correlation of fetotoxicity induced by salicylic acid (SA) analogues to their hypocalcemic effect. Among of SA analogues, acetylsalicylic acid, salicylaldehyde, salicyl-alcohol, methyl salicylate and SA evoked a hypocalcemia in rats and mice but the other analogues had no effect by their single administration. The additional administration of dihydroxybenzoic acids elicited the hypocalcemia following the fetal toxicities induced by SA analogues paralleled to that of their hypocalcemic effect. A hypocalcemic effect was induced only by the benzoic acids with hydroxy group existing in ortho-position.

摘要

在本研究中，我们调查了水杨酸（SA）类似物诱导的胚胎毒性与其降钙作用之间的相关性。在SA类似物中，乙酰水杨酸、水杨醛、水杨醇、水杨酸甲酯和SA可在大鼠和小鼠中引起低钙血症，但其他类似物单次给药则无此作用。额外给予二羟基苯甲酸后，SA类似物诱导的胚胎毒性继发低钙血症，这与其降钙作用平行。只有邻位存在羟基的苯甲酸可诱导降钙作用。