Ferrer I, Aymami A, Rovira A, Grau Veciana J M
Acta Neuropathol. 1983;59(3):167-70. doi: 10.1007/BF00703200.
A cerebral biopsy was performed in a 39-year-old male patient with subacute paraparesis who later developed severe dementia and moderate cerebellar involvement. The histological examination showed a marked neuronal loss, severe neurofibrillary degeneration, and a great number of senile plaques. No PAS-positive plaques or amyloid angiopathy could be demonstrated. Golgi's sections showed (a) meshwork of fine dendrites located distally to the soma, (b) thick, coarse dendrites full of synaptic spines in neurons otherwise lacking these structures, and (c) thick dendrites with distal varicosities and filopodium-like processes resembling growth cones. These changes have been interpreted as acquired abnormal receptor sites and represent unique facts of a group of diseases not clearly defined, including atypical Alzheimer's disease and some cases of familiar Alzheimer's disease.
对一名39岁患有亚急性截瘫的男性患者进行了脑活检，该患者后来发展为严重痴呆和中度小脑受累。组织学检查显示明显的神经元丧失、严重的神经原纤维变性和大量老年斑。未发现PAS阳性斑块或淀粉样血管病。高尔基染色切片显示：(a) 位于胞体远端的细树突网络；(b) 在原本缺乏这些结构的神经元中充满突触棘的粗大、粗糙树突；(c) 具有远端膨体和类似生长锥的丝状伪足样突起的粗大 树突。这些变化被解释为获得性异常受体位点，代表了一组未明确界定的疾病的独特特征，包括非典型阿尔茨海默病和一些家族性阿尔茨海默病病例。
