Korhonen A, Hemminki K, Vainio H
Acta Pharmacol Toxicol (Copenh). 1983 Feb;52(2):95-9. doi: 10.1111/j.1600-0773.1983.tb03409.x.
Acrolein, four methacrylates, two guanidine compounds and resorcinol were tested for embryotoxicity on three day chicken embryos. The most potent chemical was acrolein, with the ED50 0.05 mumol per egg for the total effect, including deaths and malformations. The substances next in potency were N,N'-di-o-tolyl-guanidine and N,N-diphenylguanidine, with ED50 values 0.17 and 0.20 mumol per egg, respectively. Resorcinol and the methacrylates had ED50 values ranging from 2.4 to 22.0 mumol per egg. Acrolein, diphenylguanidine, tetrahydrofururylmethacrylate and trimethylolpropanetrimethacrylate caused the largest amounts of malformed embryos.
对丙烯醛、四种甲基丙烯酸酯、两种胍类化合物和间苯二酚进行了对三日龄鸡胚的胚胎毒性测试。毒性最强的化学物质是丙烯醛，包括死亡和畸形在内的总效应的半数有效剂量（ED50）为每枚鸡蛋0.05微摩尔。毒性次之的物质是N，N'-二邻甲苯基胍和N，N-二苯基胍，其ED50值分别为每枚鸡蛋0.17和0.20微摩尔。间苯二酚和甲基丙烯酸酯的ED50值在每枚鸡蛋2.4至22.0微摩尔之间。丙烯醛、二苯基胍、甲基丙烯酸四氢糠酯和三羟甲基丙烷三甲基丙烯酸酯导致的畸形胚胎数量最多。
