Cimetidine and gastric blood flow.

The influence of cimetidine on blood flow to the gastric corpus and antrum of the dog was studied using the double isotope microsphere distribution technique. This H2 receptor antagonist caused no changes in blood flow to any portion of the stomach nor did it alter systemic circulatory parameters. The therapeutic effects of cimetidine in diffuse gastric mucosal bleeding depend on some factor other than microcirculatory changes.