Beiting C V, Kozak K J, Dreffer R L, Stinnett J D, Alexander J W
Surgery. 1978 Aug;84(2):194-200.
Whole blood vs. packed red cells for resuscitation of acute blood loss in dogs was compared with respect to a number of variables of host defense. Dogs subjected to a controlled blood loss equal to 8% of their body weight exhibited significant depressions in serum protein, C3, IgG, and total opsonic activity when resuscitated with packed red cells in saline. No such depression in serum components or activity was observed in identically bled dogs resuscitated with whole blood. There were no differences in the rate of clearance of intravenously injected bacteria indicating an intact reticuloendothelial system (RES) function in both groups. These experiments suggest that whole blood may be preferable to packed cells for resuscitation of acute hemorrhagic shock when the effect on resistance of infection is considered.
就宿主防御的多个变量而言，对犬急性失血复苏时使用全血与浓缩红细胞进行了比较。体重减轻相当于自身体重8%的犬，在用盐水中的浓缩红细胞复苏时，血清蛋白、C3、IgG和总调理活性显著降低。在用全血复苏的同等失血犬中，未观察到血清成分或活性有此类降低。两组静脉注射细菌的清除率没有差异，表明两组的网状内皮系统（RES）功能均完好。这些实验表明，当考虑对抗感染能力的影响时，急性失血性休克复苏使用全血可能比浓缩红细胞更可取。
