Terblanche J, van Hoorn-Hickman R
Surgery. 1978 Aug;84(2):206-11.
Bile duct ligation produced gross peptic ulceration of the pars esophagea of the stomach, with a 70% mortality rate from hemorrhage or perforation. The situation and histological appearance of the ulcers was identical to the peptic ulcers that occur spontaneously in pigs. Previous work has shown that these ulcers are associated with gastric hypersecretion. The technique of highly selective vagotomy was established in the pig and was shown to have no short-term adverse effects. In a group of 10 pigs, highly selective vagotomy virtually eliminated pars esophageal peptic ulceration and significantly prolonged survival after bile duct ligation. The bile duct-ligated pig experimental peptic ulcer model should be of value in studying peptic ulceration and methods of treatment. Further investigation is required to determine the cause of death in those animals in which peptic ulceration is prevented by treatment, such as highly selective vagotomy.
胆管结扎导致胃食管部出现明显的消化性溃疡，因出血或穿孔造成的死亡率为70%。溃疡的情况和组织学表现与猪自然发生的消化性溃疡相同。先前的研究表明，这些溃疡与胃酸分泌过多有关。在猪身上建立了高选择性迷走神经切断术，且该手术无短期不良反应。在一组10头猪中，高选择性迷走神经切断术几乎消除了食管部消化性溃疡，并显著延长了胆管结扎后的存活时间。胆管结扎猪实验性消化性溃疡模型在研究消化性溃疡及治疗方法方面应具有价值。需要进一步研究以确定那些通过治疗（如高选择性迷走神经切断术）预防了消化性溃疡的动物的死亡原因。
