Watson R G, Vinik A I, van Hoorn-Hickman R, Terblanche J
S Afr Med J. 1978 Dec 9;54(24):1019-21.
Pigs develop gastric ulceration spontaneously and after bile duct ligation. Despite increased basal acid secretion, serum gastrin levels are not elevated, and a possible 'protective' role of gastrin was proposed. Continuous intravenous infusion of synthetic human gastrin did not protect from gastric ulceration, but was associated with simultaneous duodenal ulceration. Another ulcerogenic mechanism must be invoked.
